Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinomaa preliminary study
- José Vicente Bagán Sebastián 1
- Yolanda Jiménez Soriano 1
- Judith Murillo Cortés 1
- Rafael Poveda Roda 1
- José María Díaz Fernández 1
- Carmen Gavaldá Esteve 1
- María Margaix Muñoz 1
- Crispian Scully 2
- Trinidad M. Alberola
- Manuela Torres Puente
- Manuel Pérez Alonso 3
- 1 University General Hospital, Valencia
- 2 University College London, London, UK
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3
Universitat de València
info
ISSN: 1698-6946
Argitalpen urtea: 2008
Alea: 13
Zenbakia: 2
Orrialdeak: 5
Mota: Artikulua
Beste argitalpen batzuk: Medicina oral, patología oral y cirugía bucal. Ed. inglesa
Laburpena
The aim of this study was to analyze proliferative verrucous leukoplakia (PVL) and oral squamous cell carcinoma (OSCC) for the possible presence of Epstein-Barr virus (EBV). We studied three groups: Sub-Group 1 was composed of 10 patients with PVL, (6 of whom had developed OSCC); Sub-Group 2 comprised 5 patients with OSCC but no preceding PVL; and Sub-Group 3 were 5 controls with clinically normal oral mucosa. Oral biopsies from all cases were examined for Epstein-Barr virus (EBV) by nested PCR. EBV was detected in 60% of Sub-Group 1 patients (PVL ) and in 40% of Sub-Group 2 (OSCC), but in 0% of SubGroup 3 (controls).