Cardiovascular response to stress in patients with drug-resistant epilepsypreliminary data

  1. Alejandro Lozano García 1
  2. Judit Catalán 12
  3. Kevin Hampel 3
  4. Vicente Villanueva 3
  5. Esperanza González-Bono 1
  6. Irene Cano-López 1
  1. 1 Universitat de València
    info

    Universitat de València

    Valencia, España

    ROR https://ror.org/043nxc105

  2. 2 Universidad Internacional de Valencia
    info

    Universidad Internacional de Valencia

    Valencia, España

    ROR https://ror.org/00gjj5n39

  3. 3 Hospital Universitario La Fe
    info

    Hospital Universitario La Fe

    Valencia, España

    ROR https://ror.org/01ar2v535

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Journal:
Anales de psicología

ISSN: 0212-9728,  1695-2294

Year of publication: 2021

Issue Title: Cerebro y conducta: un enfoque neurocientífico/psicofisiológico

Volume: 37

Issue: 3

Pages: 440-448

Type: Article

DOI: 10.6018/ANALESPS.483021 DIALNET GOOGLE SCHOLAR lock_openDIGITUM editor

More publications in: Anales de psicología

Abstract

Stress is a risk factor for cardiovascular diseases in the general population. Epilepsy has been considered a suitable model of chronic stress with a higher incidence of cardiovascular mortality than the general population. This study provides preliminary data about cardiovascular response to a cognitive stressor and a neuropsychological assessment in patients with epilepsy. It also explores the relationship between cardiovascular response and cognitive performance, depending on the side of seizure focus. Thirty-five patients with drug-resistant epilepsy, 17 with epileptogenic area (EA) in the left hemisphere (LH) and 18 with EA in the right hemisphere (RH), underwent a cognitive stressor and a neuropsychological assessment. The cardiovascular response was recorded throughout both conditions. Results showed that a long-lasting neuropsychological assessment was capable of producing a hemisphere-modulated cardiovascular response with heart rate (HR) decreases (and R-R interval increases) more pronounced in the LH patients than in the RH patients at the post-assessment period (p = .05 and p = .01, respectively). The hemisphere of EA moderated the relationship between cardiovascular response and cognitive performance (for all, p < .03). Our findings may have clinical implications from a preventive perspective since the EA hemisphere may be a relevant factor for coping with stress in people with drug-resistant epilepsy.

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Funding information

Acknowledgments.- This work was supported by the Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund (MINECO/FEDER) [grant number PSI2015-66600-P, 2015]. The authors are grateful to John Rawlins for the revision of English style and grammar.

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